BONOTEO Tablets 1mg / 50mg [Brand Name]

・This medicine may cause upper gastrointestinal disorders such as duodenal or gastric ulcers. If any symptoms such as heartburn, nausea, vomiting, blood in vomit (fresh red to brownish- or blackish-brown), abdominal pain or black stool appear, stop using this medicine and visit your doctor immediately.
・Osteonecrosis of the jaw and osteomyelitis of the jaw may occur in the patients who are using bisphosphonates including this medicine. Since such adverse reactions have reported to be associated with dental treatments such as tooth extraction, receive adequate explanations about the following points from your doctor or pharmacist:
・Maintain your oral hygiene by brushing your teeth.
・Undergo an oral or dental checkup regularly.
・Inform your dentist that you are taking this medicine when you receive dental treatment.
・Avoid any treatments such as tooth extraction as much as possible while taking this medicine.
・If abnormalities in the teeth/jaw (such as jaw pain, looseness of the teeth or swelling of the gum) occur, visit a dentist or oral surgeon immediately.
・The onset of osteonecrosis of the external auditory canal has been reported in patients who are using bisphosphonates. According to some of these cases, osteonecrosis has developed in association with ear infection or wound. If symptoms of otitis externa such as itch or pain in the ear, hotness inside the ear, otorrhea (ear discharge) or abnormal feeling in the ear persist, visit an otolaryngologist.
・For healthcare professional use only