ENTRESTO Tablets 50mg / 100mg / 200mg [Brand Name]

・For chronic heart failure:
・This product is available in 50mg, 100mg and 200mg tablets. Select the strength prescribed by your doctor from the options above.
・[for adults] In general, for adults, take 50 mg of sacubitril valsartan at a time, twice a day as the initial dose. The dosage may be increased up to 200 mg at intervals of 2 to 4 weeks in a stepwise manner if the adverse reactions do not interfere with the treatment. ・The dose is 50 mg, 100 mg or 200 mg at a time. The dosage may be adjusted according to the tolerability.
・[for children] In general, for children aged 1 year or older, take sacubitril valsartan at the starting dose based on body weight (details are described below) twice daily. If tolerated, the dose may be gradually increased to the target dose at 2 to 4 weeks intervals. The dosage may be adjusted according to tolerability.
・=Details of dosage for children (single dose)=
・The starting dose per administration based on body weight is 0.8 mg/kg for under 40 kg, 0.8 mg/kg for 40 kg or over but under 50 kg, and 50 mg for over 50 kg. The first ascending dose will be 1.6 mg/kg for under 40 kg, 50 mg for 40 kg or over but under 50 kg, and 100 mg for over 50 kg. The second ascending dose will be 2.3 mg/kg for under 40 kg, 100 mg for 40 kg or over but under 50 kg, and 150 mg for over 50 kg. The target dose is 3.1 mg/kg for under 40 kg, 150 mg for 40 kg or over but under 50 kg, and 200 mg for over 50 kg.
・The starting dose may be started with the first ascending dose depending on your previous treatment history and condition.
・*For Children, prepared syrup (suspension) may be given.
・For hypertension: In general, for adults, take 200 mg of sacubitril valsartan at a time, once a day. The dosage should be adjusted according to the age or symptoms. The maximum dose is up to 400 mg at a time, once a day.
・In any case, strictly follow the instructions.
・The initial dose may be started at 100 mg once daily for the treatment of hypertension depending on your condition.
・If you miss a dose, take a dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.